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Market: Overview Histone deacetylase inhibitors (HDIs, HDAC inhibitors, HDACi) are chemical compounds that interfere with and inhibit histone deacetylases. Histone deacetylases inhibitors are a new class of anti-cancer agents. HDACs play an important role in non-epigenetic and epigenetic regulations including apoptosis, cell cycle, and death apoptosis. Histone deacetylase inhibitors are emerging compounds with potential application in prognosis, treatment, and diagnosis of cancer. Histone deacetylase inhibitors accumulate acetylated nuclear histone in normal tissues and tumors. Hence, the inhibition results in acetylation transcription factors including estrogen receptor-alpha, p53, and GATA-1. These enzymes are found in plants, animals, bacteria, and fungi. There are about 18 known human HDACs, which are classified into four classes based on their structures. Class I includes histone deacetylase 1, histone deacetylase 2, histone deacetylase 3, and histone deacetylase 8. Class II includes histone deacetylase 4, histone deacetylase 5, histone deacetylase 7, and histone deacetylase 9. Class III includes histone deacetylase 6 and histone deacetylase 10, whereas class IV includes histone deacetylase 11.
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Market: Key Trends The global histone deacetylase inhibitors market is projected to grow at a rapid pace during the forecast period. Rise in prevalence of cancer across the globe resulting in the increase in the need for improved and effective therapies is a major factor anticipated to drive the global histone deacetylase inhibitors market during the forecast period. According to the World Health Organization, cancer is the second major cause of death globally. Cancer accounted for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 deaths occurs due to cancer and about 70% of deaths occur in low and middle income countries. Additionally, increase in collaboration among histone deacetylase inhibitors manufacturers and research & development on treatment of cancer and other chronic diseases are expected to propel the global histone deacetylase inhibitors market. However, uncertainty issues and inadequate reimbursement for histone deacetylase inhibitors are likely to restrain the global market during the forecast period.
Market: Segmentation The global histone deacetylase inhibitors market can be segmented based on class, application and end-user. In terms of class, the market can be classified into class I HDACs, class II HDACs, class III HDACs, and class IV HDACs. Based on application, the global histone deacetylase inhibitors market can be categorized into neurology, oncology, and others. Oncology is expected to be a major segment of the market due to large patient population and increase in the need for newer therapies to treat cancer. FDA-approved products currently available in the market include Vidaza, orinostat (Zolinza), Dacogen, and Romidepsin (Istodax). However, pharmaceutical companies are investing in R&D and pre-clinical activities of histone deacetylase inhibitors for treatment of different diseases. In terms of end-user, the market can be divided into hospitals, specialty clinics, and research & academic institutes.
Market: Regional Analysis Based on region, the global histone deacetylase inhibitors market can be segmented into North America, Asia Pacific, Europe, Latin America, and Middle East & Africa. North America is projected to lead the global market during the forecast period, followed by Europe. Dominance of the two regions is attributed to high income of the population, high R&D spending capacity, early adoption of innovative therapeutics, and well-established health care infrastructure. Asia Pacific is expected to be the fastest growing market owing to improved health care infrastructure, increase in cancer patient population, and rise in government initiatives.
Market: Competitive Landscape Key players operating in the global histone deacetylase inhibitors market include Celleron Therapeutics Ltd., Novartis International AG, Pfizer, Inc., Celgene Corporation, Eisai Co., Ltd., Merck & Co., AstraZeneca plc, Acetylon Pharmaceuticals, Inc., and Envivo Pharmaceuticals. The report offers a comprehensive evaluation of the market. It does so via in-depth qualitative insights, historical data, and verifiable projections about market size. The projections featured in the report have been derived using proven research methodologies and assumptions. By doing so, the research report serves as a repository of analysis and information for every facet of the market, including but not limited to: Regional markets, technology, types, and applications. The study is a source of reliable data on: Market segments and sub-segments Market trends and dynamics Supply and demand Market size Current trends/opportunities/challenges Competitive landscape Technological breakthroughs Value chain and stakeholder analysis The regional analysis covers: North America (U.S. and Canada) Latin America (Mexico, Brazil, Peru, Chile, and others) Western Europe (Germany, U.K., France, Spain, Italy, Nordic countries, Belgium, Netherlands, and Luxembourg) Eastern Europe (Poland and Russia) Asia Pacific (China, India, Japan, ASEAN, Australia, and New Zealand) Middle East and Africa (GCC, Southern Africa, and North Africa) The report has been compiled through extensive primary research (through interviews, surveys, and observations of seasoned analysts) and secondary research (which entails reputable paid sources, trade journals, and industry body databases). The report also features a complete qualitative and quantitative assessment by analyzing data gathered from industry analysts and market participants across key points in the industry’s value chain. A separate analysis of prevailing trends in the parent market, macro- and micro-economic indicators, and regulations and mandates is included under the purview of the study. By doing so, the report projects the attractiveness of each major segment over the forecast period. Highlights of the report: A complete backdrop analysis, which includes an assessment of the parent market Important changes in market dynamics Market segmentation up to the second or third level Historical, current, and projected size of the market from the standpoint of both value and volume Reporting and evaluation of recent industry developments Market shares and strategies of key players Emerging niche segments and regional markets An objective assessment of the trajectory of the market Recommendations to companies for strengthening their foothold in the market Note: Although care has been taken to maintain the highest levels of accuracy in TMR’s reports, recent market/vendor-specific changes may take time to reflect in the analysis.
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